Sentence examples for most recurrent alteration from inspiring English sources

A new finding was frequent chromosomal losses in RNO5q32 (in 20/28 of tumors, 71%), which represented the second most recurrent alteration observed in the present work.

As shown in Table 4, deletion in the locus encompassing SEC11L3 (18q21.32) was observed to be the most recurrent alteration (13 out of 19 samples; 68%).

IntOGen aims at facilitating the detection of the most recurrent alterations that drive tumorigenesis.

Since RNO10, 12 and 20 displayed the most recurrent alterations (over 20%) in the M-CGH analysis we chose an average distance between BAC clones of 0.46 to 0.92 Mb for these three chromosomes on the array.

The majority of ER-positive breast tumors overexpressing 14-3-3ζ 14-3-3ζ 14-3-3ζinal B subtype, tumors were a pofrer outheme compared with luminal A. Consistent with this, comparative genomic hyBridization analysubtypee indicatumorsat one of the most recurrent alterations in luminal B tumors is gain/amplification of the 8q region that harbors 14-3-3ζ (8q22) [ 36].

On the other hand, an extra copy of chromosome 20 has been known to be the most recurrent cytogenetic alteration in hepatoblastoma [ 2, 34].

Several approaches have been proposed to identify the most relevant recurrent alterations across a large number of tumor samples.

Since most of the recurrent alterations present in a primary tumor are retained in the corresponding cell line, this system has provided invaluable insights into the role played by deregulated genomic and transcriptional pathways in mammary oncogenesis [ 58].

Overall, with the exception of alterations in DNMT3A, the most recurrent mutations within ERG families were associated with loss of function.

The mitochondrion represents the most recurrent target, and the intensity of the alterations in this organelle is time dependent and varies with the compound employed [ 30, 104, 105].

It is consistent with the finding of no specific alterations for MSI tumors, the most recurrent gains in MSI tumors being also observed in MSS tumors.