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Only three PRCs used formal procedures for systematically collecting and reviewing the research evidence during their most recent prenatal record review process.
Other eligible participants were any core or ad-hoc PRC members who participated in the jurisdiction's most recent prenatal record review.
Interviews will address potential internal and external contextual factors as well as different types and sources of evidence that may have contributed to decisions around prenatal record content made during the province's most recent prenatal record revision.
Many PRCs across Canada indicated that their most recent prenatal record review was driven in part by the need to include more content on the social determinants of health, suggesting the need for more guidance in this area.
Primary reasons given for initiating their most recent prenatal record review were to include more content related to the determinants of health (e.g., stress, smoking, alcohol use, domestic violence) and to integrate new national guidelines related to such topics as genetic screening and maternal serum screening.
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In summary, of the three most recent longitudinal studies that measured prenatal lead exposure (average blood lead ranging from 1 to 11.5 μg/dL), two found a negative association with subsequent IQ, and one found no effect.
Demographic characteristics were recorded and a standardized questionnaire was completed, documenting sexually transmitted infection symptoms, sexual behavior, previous birth outcomes, relevant obstetric and prenatal histories, and most recent CD4 T cell count.
In the most recent group, the percentage of no prenatal SHS exposure (cord blood cotinine 0.2-1 ng/mL) showed an increase compared to the previous groups while the percentages of both: low (1.1-14 ng/mL) and very high (> 100 ng/mL) prenatal SHS exposure showed a decrease.
The most recent study neither adjusted for breast-feeding nor for additional prenatal methylmercury (MeHg) exposure from maternal fish consumption, but they attributed the conflicting outcomes to chance (Thompson et al. 2007).
This rate therefore varies according to the study period: as prenatal diagnosis has improved with time, the false-positive rate has become lower in the most recent studies and is now consistent with our rate.
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