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While the drug binding pocket remains unaffected by these most recent mutations, the N248D substitution changes a central part of an antibody recognition site.
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Values of ρ and σ were converted to age estimates using the most recent mutation rate available for the HVS-I segment of one transition per 18,845 years (in the sequence range 16090 16365) (Soares et al. 2009).
Our similarity measure has an evolutionary interpretation, with sequences sharing a cluster depending on the time to their most recent common mutation.
He said redheadedness was "the most recent successful human mutation", with 1-21-2% the world's population having red hair, rising to 6% in northern Europe.
Hence, to enhance the sensitivity of our analysis we focused on mutations that reflect the most recent rounds of replication, "private site mutations", defined as a mutation found in only one of the (N = 105) viral genomes sequenced.
Coincidentally the time estimate for the most recent evidence pinpointing these mutations?
The reason is that such rare alleles primarily represent relatively recent mutations, most of which will experience rapid stochastic loss [ 20].
The age of the most recent common ancestor of mutation carriers was estimated using a likelihood-based method with the ESTIAGE program, based on the length of the haplotype shared on each side of the disease locus (Genin et al., 2004).
This can be seen by the exponential increase in the number of papers reporting GluR mutations in most recent years.
The most recent report suggests that KRAS mutations are most common in extrahepatic tumours and that rates for intrahepatic cancers are on the lower end of this spectrum at 9 22% (Voss et al, 2013).
The most recent investigations showed that the mutation of AtFLN1 or AtFLN2 in Arabidopsis displayed a pale-yellow or albino cotyledons phenotype and were seedling lethal on MS medium without sucrose, and only could survive on sucrose-containing medium [ 43, 44].
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