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In most randomized controlled trials an absolute rating scale threshold is defined as remission (eg, HAM-D score ≤ 7).
13 Most randomized controlled trials reported between 7% and 53% of the 15 items; two adequately reported more than 60% of the items.
Most randomized, controlled trials (RCTs) of medication or of psychotherapy rely on clinician ratings of symptoms to assess treatment effects and to define both response and remission (Depression Guideline Panel, 1993).
However, most randomized, controlled trials with vitamin D supplementation have failed to demonstrate improved vascular function or cardiovascular outcomes [ 42- 44], suggesting that low vitamin D levels simply reflect health status, rather than directly causing disease.
Furthermore, most randomized, controlled trials exclude patients with medical comorbidities and other features commonly seen in the elderly, resulting in a very limited "evidence base" about the treatment of these patients.
In contrast, treatment with acarbose has been shown to associate with a moderate weight loss of about 1 kg, on average, compared to placebo, alongside improved glycemic control in most randomized controlled trials [ 24, 49, 50].
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This issue is of practical importance because most randomized control trials on prevention of colorectal neoplasia consider adenomas rather than cancer itself as the endpoint.
Most randomized control trials found a beneficial effect in reduction of bacterial colonization and/or VAP; however, effects on length of stay in the ICU and mortality are inconsistent.
The samples of most other randomized controlled antipsychotic drug trials are however highly selected [ 23].
However, the relative difference in response rates compared with placebo in this patient population was relatively small compared with most other earlier randomized controlled trials of TNF inhibitors in similar populations of patients naïve to TNF inhibitors or other biologics [ 11- 14, 39].
Most of the prospective randomized controlled trials and 3 meta-analyses have not found any benefit associated with these agents [185 188].
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