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This is one of the most radiosensitive parts of the human body, which means that the effective dose is substantially increased.
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Small bowel is normally considered the most radiosensitive region due to its rapidly proliferating crypt cells [ 1, 5].
The endothelial lining of the microvasculature is the most radiosensitive portion of the vasculature and severe damage results in intracellular edema with resultant vascular occlusion [ 45].
However, the alterations induced by GNPs in cell kinetics could be associated to the accumulation in G2/M which is known to be the most radiosensitive, thus increasing GNP-mediated radiosensitization.
The gastrointestinal (GI) tract is one of the most radiosensitive organs in the body.
We present a design study for a wearable radiation-shielding spacesuit, designed to protect astronauts' most radiosensitive organs.
Weight loss in animals is often an indicator of toxicity, and the most radiosensitive organs for PRRT are the bone marrow and kidney [8, 28, 29].
About the mechanism of enhanced radiosensitivity, Turner et al. reported metallic materials may arrest cells at the G2/M phase, the most radiosensitive phase of the cell cycle [33].
These assays analyzed according to the linear-quadratic model showed that α ranged from 0.37 Gy−1 (most radioresistant tumor cells) up to 0.97 Gy−1 (most radiosensitive normal cells), with a very low β/α value.
The bladder is the most radiosensitive organ in the urinary tract [9]with the incidence of radiation cystitis ranging from 3%% to 12%%, depending on total dose and volume of bladder treated [15].
Gene therapy and radiation therapy target best at different parts of the cell cycle, that is, gene therapy requires the 'S' phase of the cell cycle while 'M' and 'G2' phases are most radiosensitive (Simons and Marshall, 1998).
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