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Therefore, although dendritic Na+ spikes do have the capability of transforming synaptic inputs into neuronal outputs under certain condition; in most pyramidal neurons, they are neither sufficient nor necessary for axonal AP initiation (Hausser et al., 2000; Spruston, 2008).
Since most pyramidal neurons are not spontaneously active under chloral hydrate anaesthesia, the use of a multi-barreled electrode coupled with microiontophoretic pumps was required, so that an ejection current of quisqualate permitted to maintain pyramidal neuron firing rate within the 3 6 Hz range.
This suggests that the number of perisomatic inhibitory synapses is reduced when TrkB.T1 is expressed in most pyramidal neurons in V1.
We conclude that inhibitory perisomatic boutons formed by PV-expressing interneurons are reduced only when most pyramidal neurons in V1 express the TrkBT1 transgene.
Finally, we demonstrate that inhibitory synapses onto pyramidal neurons are reduced when TrkB signaling is interfered with in most pyramidal neurons but not when few pyramidal neurons have this deficit.
Examination of hippocampal sections following injection of BrdU at E14.5, a time at which most pyramidal neurons are born (Angevine, 1965), revealed disorganization in Ammon's horn affecting both CA1 and CA3 regions.
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Adenosine decreased cellular excitability of most pyramidal neuron subtypes via adenosine A1 receptors that lead to the opening of potassium channels.
The radial glial cell, a transient embryonic cell type known for its crucial role in neuronal migration, has recently been shown to function as a neuronal progenitor cell and appears to produce most cortical pyramidal neurons.
This line was crossed to 2 different cre-transgenic lines, which dictated whether the TrkB.T1-EGFP transgene was activated in sparse or most cortical pyramidal neurons.
Additionally, we show that interneurons not expressing the TrkB.T1 transgene may have a competitive advantage and obtain more excitatory synapses when most neighboring pyramidal neurons do express the transgene.
To study the differential effects of TrkB.T1 expression in sparse or most cortical pyramidal neurons in the young adult visual cortex, we made use of mouse line TLT-817, which carries a transgene containing the Thy1-promoter-driving expression of TrkB.T1 fused to EGFP in a cre-dependent fashion.
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most caudal neurons
most mature neurons
most neighboring neurons
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most similar neurons
most inhibitory neurons
most numerous neurons
most hippocampal neurons
most vulnerable neurons
most large neurons
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