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It's no surprise that most published trials funded by drug companies show positive results.
In most published trials authors' conclusions favoured the experimental intervention (figure 1).
In the absence of objective markers, most published trials define a moderate-severe exacerbation as one requiring admission to hospital or intravenous antibiotics.
Notably, most published trials do not report any information on incident malignancies; cases could be easily identified only in trials reported on the GSK Web site (11), which contains a detailed description of all serious adverse events.
(Table 2) Most published trials to date have had between 30 and 50 participants and have been under-powered to detect important clinical outcomes such as major haemorrhage and anaemia.
This is important because most published trials have reported a non-significant trend towards a shorter duration of pregnancy after the use of progestogens in women with a multiple pregnancy [ 8, 9, 21, 22].
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References were also sought from the most recently published trials, editorials, and commentaries (a top-down approach).
On the other hand, one of the most recently published trials, by Engstrom et al, 14 is in opposition to this argument.
The previous consensus conference on PAC use must then be revisited in light of the most recently published trials and meta-analyses.
Although for patients with BDC the response rates and median overall survival in our trial do not exceed the results reported for the use of chemotherapy doublets, median overall survival for GBC compares favourably with most other published trials.
In recent years, most of the published trials of new antiepileptic drugs (AEDs) have had a parallel-group design rather than cross-over.
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