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This accuracy is comparable with most published nomograms for cancer prognosis.
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We would like to address some limitations of our study, factors common to most published nomogram development series.
This study was undertaken to construct an institution-specific transverse cerebellar (transcerebellar) diameter nomogram with special emphasis in the third trimester and to compare its ability to predict gestational age with previously published nomograms.
The GRACE in-hospital risk score (range 0 372) and the GRACE 6-month risk score (range 0 263) were derived from the GRACE registry for the endpoint of all-cause mortality and consist of eight and nine variables, respectively (Table 3), with published nomograms outlining the conversion of each variable to its corresponding point value [6], [7].
Three of the six external validation studies were based on published nomograms where the underlying regression model was not reported in the original publication (only a link to a web calculator).
The CAHP score was calculated based on the previously published nomogram [22].
Theoretically, the published nomogram offers the advantage of condensing the high heterogeneity of the disease into a simple and easily interpretable format to guide the decision-making process towards the most adapted treatment options or follow-up strategies.
Nevertheless, this fact does not represent a limitation to validate the published nomogram.
This is line with previously published nomogram models (Karakiewicz et al, 2007; Jeldres et al, 2010).
Further, the published nomogram has not been validated by other institutions.
Pre-operative nomogram score gave excellent separation of the CSS, OS and DFS curves with similar survival estimates to the original published nomogram estimates (Karakiewicz et al, 2009).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com