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The primary reason behind this confusion is limited validity of most published methods to a few working fluids and narrow ranges of operating conditions.
Most published methods do not enable studying the stability of this drug in different stress conditions.
Although, most published methods do not specify the survey time or swim speed of the belt-transect diver [8], [9], [18], [22], we set survey time to 300 s which is a commonly reported deployment time used for the stationary-point-count and belt-transect methods [7], [19], [21] and diver speed to 4 m·min−1, which is a reasonable speed for counting conspicuous fishes.
Most published methods in this area either are inaccurate or require lots of manual interactions.
Most published methods used to identify cis-regulatory elements build upon a priori knowledge of regulatory structures or expression patterns.
Retrieving haplotype information from NGS reads is not entirely new, but most published methods specialize in germline polymorphisms and typically rely on population genetics information [ 9].
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The most recently published methods of evolutionary rate-shift analysis (testing for type I functional divergence) enable large-scale analysis.
Results: Here we introduce CCMpred, our performance-optimized PLM implementation in C and CUDA C. Using graphics cards in the price range of current six-core processors, CCMpred can predict contacts for typical alignments 35 113 times faster and with the same precision as the most accurate published methods.
The detection limit of DWO RRS was 1.1 nmol L−1 (0.5 μg/kg), which was lower than or comparable to most of the published methods.
Some of the limitations of the method proposed in this study are shared by most of the published methods: marker alleles are assumed to be selectively neutral, mating within the population is at random and immigration from other populations is absent (Leberg 2005).
Our method predicts zinc-binding residues with 75% precision (86% for Cys and His only) at 50% recall (the number of predicted zinc-binding residues out of all zinc-binding residues) when tested on a non-redundant set of SCOP (Structural Classification of Proteins) containing 2727 domains, which is 10% higher in accuracy than the most recently published method (Passerini et al., 2006).
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