Sentence examples for most proximal mediators from inspiring English sources

This is surprising, given that these PI3Ks generate the PtdIns 3,4,5) P3 lipid substrate for PTEN, and that they are ultimately the most proximal mediators of the lipid kinase-dependent impact of PTEN inactivation.

Although downstream mediators (cytokines) and effector cells (phagocytes) have been identified, proximal mediators originating from injured tissues remained elusive.

A proximal reference wire was fixed and tensioned to the most proximal ring.

Removal of some of the most proximal pins (those fixing the proximal osteotomy) once it shows signs of satisfactory healing.

The most proximal intervention to prevent painkiller (opioid) overdose deaths is to administer, either intravenously or intranasal, naloxone, an FDA-approved medication with well-established efficacy and safety.

This approach is so far the most proximal surrogate to study the function of PrP.

Villi at the most proximal end of the small intestine were used for length measurements.

Its unique properties suggest that it is the attachment factor most proximal to the γTuRC.

The base of the most proximal filopodia was considered as the beginning of the growth cone.

In both genomes, the intervening ORFs most proximal to the rrl are homologous putative heptosyltransferase genes.

In the most proximal sample, the medullary cavity is surrounded by a sharp line.