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However, most protein complexes are stable complexes in which the proteins are recovered at equal abundance levels, hence determining the connectivity between proteins in those complexes solely from quantitative proteomics experiments remains a major challenge.
In the absence of most protein complexes in the OXPHOS pathway, its function remains unclear.
Most protein complexes are essential for viability, though not every component of a given complex is essential.
For this relatively simple organism, the study of protein complexes is now being performed genome wide and the elucidation of most protein complexes of the yeast is undergoing.
Most protein complexes adopt symmetry to some extent, so here we initially assume that the sphere-modeled hexamer will follow C2 symmetry.
By analogy, it can be hypothesized that most protein complexes exert growth-rate control when cells are growing rapidly, though not every gene that encodes a component of a particular has a significant flux control coefficient (Fcoefficient
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Most protein complex prediction algorithms have employed a form of local search to expand seeds by including proteins located in the seeds' local neighbourhood graph.
Most protein complex subunits can probably be duplicated with little phenotypic effect, a situation that would not be true if over-expressing subunits more frequently disrupted the activity of complexes.
To keep in line with most previous studies, we calculate precision, recall and F-score in this study, and also report Sn, PPV and Acc. Most protein complex prediction studies reported to date have involved Saccharomyces cerevisiae.
One of the most important protein complexes involved in maintaining correct RNA levels in eukaryotic cells is the exosome, a complex consisting almost exclusively of exoribonucleolytic proteins.
Dimerization of HER3 with HER2 is known to be one of the most mitogenic protein complexes [24] and is frequently implicated as a potential drug resistance mechanism [25], [26].
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