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Although PV-neuron loss was observed in all regions of hippocampus, as well as prefrontal cortex, the most pronounced decrease was in CA2-3.
While the rate of proliferation decreased in the cells transfected with Akt1- and Akt3-siRNA, cells void of Akt2 consistently showed the most pronounced decrease in proliferation among the three isoforms (Fig. 1C and Fig. S1C, D).
A significant reduction (P<0.001) in mean Foxn1 fluorescence intensity was detected in both cTECs and mTECs, with the most pronounced decrease apparent in cTECs which changed from a mean of 181 (ST) to a mean of 112 (TetO-Dkk1) representing a 40% decrease in Foxn1 expression.
The most pronounced decrease in cycling cells was observed in the MHCIIlow EpCAMlow subset resembling the recently identified cTEC progenitors [91], and supporting a role for Wnt signaling in maintaining TEC progenitor/stem cell populations or promoting the development of their immediate progeny.
The most pronounced decrease was induced by BRB.
The erg6Δ haploid deletion induced the most pronounced decrease in ERG6 rank predictions.
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Finally, PM2.5 concentrations are projected to decrease over time, with the most pronounced decreases in areas with the highest estimated concentrations in 2001.
The most pronounced decreases were observed in patients with severe sepsis with shock, followed by the severe sepsis group without shock and the patients with SIRS without infections.
The most pronounced decreased hazard was observed between the inactive (reference) and moderately inactive groups in both the abdominally lean (HR: 0.75; 95% CI: 0.72, 0.78) and abdominally obese (HR: 0.79; 95% CI: 0.75, 0.84) groups.
In parallel to HbA1c values, levels of CRP were lowered in a dose-dependent, U-shaped fashion (Fig. 2 F – I ), with the most pronounced decreases at the earlier time points.
Intriguingly, the exposure-specific production of major metabolites (phenol, muconic acid, hydroquinone, and catechol, in micromolar per parts per million benzene) decreased continuously with estimated exposure levels over the range of 0.03 88.9 ppm, with the most pronounced decreases occurring at benzene concentrations < 1 ppm (Kim et al. 2006a).
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