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The most promising formulation was subsequently used for in vivo multiple oral administration studies using diabetic rats.
Utilizing the various formulation screening tools, it was determined that a colloidal dispersion of the drug would be the most promising formulation approach.
For the most promising formulation, the ability to improve mechanical properties and reduce solubility in water of treated stuccoes was investigated.
The objective of the present work is the systematic assessment and selection of the most promising formulation and setup parameters of multi-objective deterministic particle swarm optimization (MODPSO) for simulation-based problems.
The most promising formulation was found to be GLNG-3 containing the highest quantity of Guggul lipid among all formulations.
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The most promising formulations were produced in small scale fluidized bed application runs and analyzed by dissolution tests and complementary analytical assays.
Starch-based microparticle formulations from the experimental plans were compared and characterized through particle size analysis, scanning electron microscopy, elemental analysis and, for the most promising formulations, by in vitro labeling stability studies and determination of free polyamine content or in vivo imaging studies.
Future improvements in the pure component properties, thermodynamic model and distribution model of fatty acids in the triacylglycerols can increase the use of computational approaches allowing the experiments to be focused on the most promising formulations in terms of melting profile.
The most promising stable formulation was developed with Vitamin E TPGS + HPMC submicron suspension, which produced higher permeation rate compared to other vehicles.
Based on the adsorption profile to HA and the in vitro stability in phosphate buffer, the most promising liposomal formulation to target for human enamel in this study was the positively charged DPPC liposomes with 10 mol% charged lipid included.
The most promising NEM formulations were selected on the basis of bulk and flow properties, distribution of NPs in the carrier and aerosolization performance upon delivery through a breath-actuated dry powder inhaler.
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