Of these, the ethyl acetate and aqueous fractions showed the most promising, dose-dependent hepatoprotection in DCFH-toxicated cells at 48 h.
Because it will not be possible to test many agents in large randomized clinical trials, efforts are underway to develop useful tissue-based surrogate end-point biomarkers that can be used to select only the most promising agents (and doses) for large-scale trials.
Since it will not be possible to test many agents in large randomized clinical trials, efforts are underway to develop useful tissue-based surrogate end-point biomarkers that can be used to select only the most promising agents (and doses) for large-scale trials.
The most promising strategies for dose adjustment and therapeutic schemes are discussed.
Since the disease struck, Department of Agriculture scientists have combed the country for resistant elms, propagating the most promising and inoculating them with huge doses of Dutch elm disease.
Moreover, the quantification of the levels of CSF α-synuclein oligomers at the baseline and during the treatment would assist with the identification of the most promising and effective drug candidates and doses in large-scale clinical trials.
In left-sided breast cancer irradiation, IMPT is the most promising technique to maximally reduce the dose to heart and LAD-region, even without a breath-hold technique.
In this study we focus on the most promising inhibitor, 5D9, because it exhibited the highest, dose-dependent, reproducible inhibition of FMDV at 24-hours after infection.
One of the most promising combinations of these methodologies consists of low-dose spiral computer tomography (CT) with a companion serum test (Ashton and Jett, 2005; Wardwell and Massion, 2005).
And the most promising compound 7c was further studied in terms of dose-dependent, time-dependent and cell apoptosis.
We specifically focused on the effects of low doses of 5-AZA-CdR that have shown the most promising therapeutic activity in initial clinical trials in cancer patients (Daskalakis et al, 2010).
