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Most promising compound 17 has shown promise for further development as a double-edged vaginal microbicide due to their improved activity and safety along with notable in vivo trichomonicidal activity.
The most promising compound showed inhibitory activity IC50 = 60.2 μM.
Furthermore, pharmacokinetic properties of this most promising compound are profiled.
The most promising compound, BIT1, was radiolabelled by using the corresponding nitro precursor.
In particular, chondroitin sulfate (CS) appears as the most promising compound.
Therefore, compound 7b is the most promising compound for further studies on antimalarial chemotherapy.
The most promising compound 9 significantly inhibited (P < 0.001) thiol-sensitive sperm hexokinase.
Furthermore compound 10d was identified as most promising compound with 12 fold selectivity against butyrylcholinesterase (BuChE).
Together, the most promising compound 4o might serve as a novel hDHODH inhibitors for further investigation.
The most promising compound was synthesised and it exhibited a submicromolar inhibition of the HCV helicase.
The most promising compound b20 is more active than the standard drug (Table 22, Fig. 6) [30].
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Justyna Jupowicz-Kozak
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