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Genes that were most prominently regulated by PPARα were involved in lipid metabolism (Cyp4a10, Abca1, and Smct1).
However, the figure allows extracting the most prominently regulated genes for the oncogenic or wild-type situation based on the provided heat map.
It is particularly intriguing that one of the most prominently regulated miRNAs resides on the Z chromosome, present in two copies in males, the homogametic sex in birds.
Further, a pathway analysis of the differentially expressed genes showed that the SAPK-JNK, p38 and MAPK pathways belong to the most prominently regulated signaling pathways in FH monocytes.
Strikingly, Col1a1 was the most prominently regulated gene, showing a 2.5-fold downregulation in Aga2 severe, confirmed by 4-fold Col1a1 repression compared with WT by qRT PCR (Fig. 2D).
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ADAMTS-4 is expressed constitutively, whereas ADAMTS-5 is more prominently regulated by inflammatory cytokines.
This sentence should read: ADAMTS-5 is expressed constitutively, whereas ADAMTS-4 is more prominently regulated by inflammatory cytokines.
As with LTC4S expression, the expression of the CysLT receptors is regulated by cytokines, including, most prominently, by IL-4 and IFN-γ.
The vast majority of human cancers lack functional p53, a key tumor-suppressor protein that regulates various cellular stress responses, most prominently that induced by DNA damage.
Most prominently p16INK4a, p19ARF have been shown to be negatively regulated by Bmi1 [27].
The top three most highly enriched clusters of genes that correlated with the agonist groups of miRNAs (most prominently miR-17) suggested that the agonistic miRNAs positively regulate cell cycle and DNA replication.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com