One of most prominent events downstream of nucleolar stress is activation of the p53 tumour suppressor protein, a key regulator of stress-induced apoptosis, DNA repair, cell cycle arrest, and senescence [ 18, 22, 42- 44, 46, 48, 50, 118, 119].
In addition, the enrichment analysis showed that MYC targets were significantly enriched in all 8 processes and JUN targets were enriched in 6 out of the 8 processes, indicating that MYC and JUN are the two most prominent TFs downstream of PDGF in pBSMCs.
Kruppel like factor-5 appears to be at the top of the hierarchy activating several downstream transcription factors, the most prominent of which is peroxisome proliferator activator receptor-γ.
The most prominent of these was located 53 kb downstream of SCL P1a (+53) and showed particularly high levels of H3 K4me3.
As shown in Fig 2D, the map revealed increased density of RBM10 binding clusters close to the splice sites of both introns flanking the skipped cassette exons, with the most prominent enrichment at 3′ splice site of downstream intron.
For FUS peaks, the most prominent intersection with RNAPII peaks was for peaks localized downstream (91%%) (Fig. 5b).
Further, we tested the role of stress-activated kinase p38 (in complex with MK-2, a direct downstream target of p38) as the most prominent mediator of stress-induced cellular senescence.
Indeed, Ca2+ is the most prominent messenger required through these cycle points [ 65, 66] and downstream targets of Ca2+ have also been implicated in cell cycle progression as well [ 67, 68].
The most prominent feature of proteins in WRKY TFs is the WRKY domain, which preferentially binds to the promoter of their downstream target genes on a specific cis-element (e.g. W-box).
