Perhaps the most prominent effect of developmental DES exposure in the reproductive tract of male mice is a permanent inability of the SVs to reach and maintain their normal size during adulthood.
Although a large number of transgenic TcLEC2 embryos were obtained, most of them exhibited prominent developmental and morphological abnormalities, and most ceased development at the globular or heart stage and the initiations of cotyledons were significantly compromised.
The most prominent epigenetic modifications associated with developmental regulation of gene expression include methylation of DNA at the CpG dinucleotides by DNA methyltransferases and the post-translation modifications of histones [5], [6].
In the course of the disease, neurological signs are most prominent including sensorineural deafness (9/9), developmental delay (8/10), epileptic seizures (6/9), dystonia (5/9), optic atrophy (6/10), muscular hypotonia (6/10), and spastic paresis (2/10).
Developmental neurotoxicity is one of the most prominent off-target toxic risks of insecticides.
A number of physical and mental changes accompany the developmental process of ageing; some of the most prominent of these involve changes in memory function.
All six patients had moderate-to-severe developmental delay, with motor delays being the most prominent and severe.
The Joint Statement of Early Childhood Health and Education Professionals on the Common Core Standards Initiative was signed by educators, pediatricians, developmental psychologists, and researchers, including many of the most prominent members of those fields.
In our studies, carried out at stage 16/17, the increase in TUNEL positive cells was most prominent outside of the neural crest stage Slug expression domain, and so presumably represent effects on earlier developmental events.
