Exact(3)
Experiments observing the steady-state pattern of chimeric labeled mouse embryonic stem cells [36], and pulse-lineage-labeled newborn Clara cells [17] show that for homeostasis of the intrapulmonary respiratory epithelium, most progenitor cells (e.g. Clara cells) are randomly distributed throughout the bronchioles and are not associated with particular anatomical niches.
Importantly, the expression of most progenitor marker genes was significantly increased in P240 PR-SET7 ΔHepA liver tumors (Supplementary Fig S7B).
In this study, we show that when neuroblasts enter quiescence, the differentiation factor Prospero is transiently detected in the neuroblast nucleus, followed by the establishment of a unique molecular profile lacking most progenitor and differentiation markers.
Similar(57)
We suggest a speculative model for Prospero function: low levels of Prospero are sufficient to repress most progenitor-specific genes in neuroblasts (worniu, asense, miranda, and cycE) but do not repress the expression of deadpan (perhaps due to lack of high affinity Prospero binding sites).
Under homeostatic conditions, most progenitors remain in the bone marrow compartment, retained by high SDF-1α expression, which is maintained by the hypoxic microenvironment.
Consistent with previous studies, the metaphase spindles of most progenitors, as reported by the chromosome plates, continuously changed their angles with respect to the apical basal axis until anaphase, and did so in apparently random fashion.
The domain of axin2 expression also was expanded proximally in BMPRi-exposed fish, further indicating that BMP functions in proximal osteoblasts to restrain Wnt activity to the distal-most progenitor pool.
While the vast majority of ILC1 cells develop from PLZF-expressing common ILC progenitors, most cNK progenitors do not express PLZF.
In hematopoietic system, the ABCG2 expression is confined to the most immature progenitor cells and down-regulated at the committed progenitor level [ 36].
The majority of CML progenitors were found to have a higher proliferative capacity compared to normal progenitors, suggesting that most CML progenitors were actively cycling (Eaves et al., 1998).
Its most obvious progenitor is the long-running "Bushisms" series, in which Jacob Weisberg, of Slate, compiled the most egregious malapropisms of the misunderestimated forty-third President.
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