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In this soliloquy, Hamlet's most seeming-simple question of course propels us into one of the English language's most profound reflections on the painfully unknown relationship between life, death, and what comes after.
It's apt to note, days after the reissue of "Shoah," that the selection of Saul Bellow's letters that ran in the April 26th issue of the magazine (available to subscribers) features one of the most profound reflections on the Holocaust that I've ever read.
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Style is the most profound expression of personality".
But the finest musicianship of the night, worth all the rest, came in the second-movement andante, where the softness, slowness and simplicity of Barenboim's playing in the final bars seemed to unlock the most private and profound reflections of the composer.
Remembrance is most profound when it is personal, informed, voluntary and involves reflection and empathy.
He wanted to discuss Madewela's reflections on pain, which were by far the most profound things they had heard this week, he thought.
Along with seemingly profound reflections on cultural forms, descriptions of these walks constitute most of Open City, the first full-length novel by Teju Cole, which has been much praised in the United States for its prose style and for its take on the city as a site of power, desire and community.
In education jargon, there is a most profound "learning outcome": a vivid sense of the indignities and humiliations, along with the "rueings" and reflections, of a patient undergoing experimental chemotherapy for stage-four metastatic ovarian cancer ("there is no stage five").
The most profound lyrics?
What might be their most profound worry?
But the most profound is psychological.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com