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The majority of the most profound developmental events – the establishment of the body axes, the differentiation of germ layers, and the appearance of organs and structures – occur with remarkable speed: within the first 2 months of life in humans, and much faster in the animal models that we typically use to study development.
Emergence of multicellular organisms was one of the most profound developmental transitions in the history of life [ 28].
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These developmental analyses demonstrate that the most profound phenotype caused by Nde1 mutations is characterized by DNA damage and apoptosis, and that this phenotype is spatiotemporally in parallel to the early differentiation period of neural progenitors.
This abrupt change in the number of effective expressed genes indicates that the last developmental period examined (from 40 to 60 DAA) was the one characterized by the most profound changes in the transcriptome.
The most profound lyrics?
What might be their most profound worry?
But the most profound is psychological.
Environmental dilemmas are among the most profound challenges facing humanity.
What has been the most profound change?
It represents our most profound political belief.
Here, sites with the most profound impact.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com