We have found that all of the mad and bub mutations perturb Cdc20p turnover, and lead to a range of increased stability with mad3Δ having the most profound effect (data not shown).
Long known for its copper, sea bass and merlot wine, Chile's most profound export may be data that its astronomical observatories mine nightly from its pristine skies.
The segregation into two subtypes is most profound for the TCGA and KFSYSCC data sets, both showing a similar pattern that is consistent with the S/N data set.
The value of these approaches is likely to be most profound in low-income settings where data are scarce, but methods of analysis are still in their infancy, as are effective protocols for sharing the data more widely.
Previously reported [ 35] and our unpublished data suggest that the most profound autophagic response in tumour cells is triggered by starvation for arginine, methionine, lysine, and leucine relative to other amino acids.
In fact, the big data movement — organizations scrambling to make sense of all this data — may be the single most profound trend that the Web has created in the past 12 months.
At the same time, the information that potentially has the most profound impacts on customer experience customer support feedback, product usage data, connected device data frequently remains confined within departments, application silos or personal computers, or is simply not collected.
"The most profound shift is in the fact that the data underneath the applications of Office 365 is exposed in a graph structure.
These intervals were chosen based on existing literature data, according to which the most profound structural changes in the brain after occlusion of middle cerebral artery in rats are seen on 6th and 12th days [ 20, 21].
In his reporting, he used data and statistics, but perhaps the most profound moment was when he interviewed families affected by the failing foundation.
