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By contrast, the current-voltage (I/V) relations for GluR2-lacking (Ca2+-permeable) AMPAR channels is inwardly rectifying, so that channel conductance and Ca2+ influx through GluR2-lacking AMPARs is most profound at negative (i.e. hyperpolarized) membrane potentials.
Altogether, these results show a stimulatory effect of 100 ng/ml rhBMP-7 on matrix anabolism, which seemed most profound at day 7, and an anti-apoptotic effect, which seemed most profound at day 28.
In this model, the effect of potential HCW staff shortage is most profound at a 50% ICU admission rate.
The sensation of airflow is most profound at the skin-lined vestibule where end-sensory mechanoreceptors serve to refine the tactile perception.
Following IR, HCT116 cells were shown to have a time-dependent HIF1 α protein decrease, which was most profound at recovery, and therefore antithetically followed p53 protein expression.
The results of the present study showed that the major deregulation of miRNAs in NT placentas to be most profound at day 50 of pregnancy.
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But it is Morales who has brought about the most profound change at Vancouver.
This experience may be the most profound idea at the show.
The grave effects of internal emitters are of the most profound concern at Fukushima.
At the United Nations, the General Assembly was called into plenary session and the Secretary General, U Thant, simply said that it was his solemn duty to express for all of them "the most profound sorrow at this tragic event and to convey our condolences to the family and to the Government and people of the United States".
I had the most profound experience at that party; it was nothing like anything I had ever been to.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com