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In the most problematic cases, some patients are blind, others are deaf, and others have dementia or muscle disorders.
But even in the most problematic cases the CDFs of the bootstrap and the according limiting distribution differed by no more than 7%%, which seems justifiable to us.
The unbiased alignment process of MSARC may simplify this procedure and improve the reconstruction accuracy, especially in the most problematic cases.
Conversely, the most problematic cases are the ACES Cascais (11) and Arco Ribeirinho (15), both located in the region of high complaints and low efficiency.
In terms of basic health services, Iraq has long been among the region's most problematic cases, with dangerously high rates of neonatal mortality and one of the lowest vaccination coverage rates.
By excluding from the analysis the most problematic cases in which one probe set is informative and the other is not we elevated the percentage of cases with good correlation [see additional file 3].
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We report in Table 2 the results obtained for the radius, representing the most problematic case.
When the plots were classified according to the ≥75 % species proportion, the most problematic case was the 'mixed' class including plots of lower dominance of the various species.
Hybridization is probably the cause of the most problematic case in the taxonomy of the R. crucifer species group.
The most problematic type of DILI is "idiosyncratic".
The issue of multiple hypotheses testing is most problematic in cases where data on a large number of explanatory variables are collected to explain some phenomenon of interest, but a priori information on which predictors (and essentially, if any) influence the response is not available.
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most difficult cases
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Justyna Jupowicz-Kozak
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