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G. Pressure pain threshold (PPT) is the only test for deep-pain sensitivity, most probably mediated by muscle C- and A-delta fibers [13, 15].
g Pressure pain threshold (PPT) is the only test for deep pain sensitivity, most probably mediated by muscle C- and A-delta fibers, with inter-stimulus interval of 60 s.
Analysis of the underlying mechanism suggests that this phenomenon depends on the activation of the pseudo-hypoxic pathway — most probably mediated by the abnormal stabilization of HIF-2α following VHL inactivation — and the loss of the p53/TIGAR pathway.
The rearrangements in LCBs four and five are most probably mediated by two large duplicated regions (DR1 and DR2) previously discussed in the genome report comparing WY96 and Schu S4 [10].
The buffering effect of increased resource supply was most probably mediated through effects on most of the reproductive parameters such as size and age at maturation, brood size, instar duration and egg development time, resulting in an increase in population growth rate [41].
This effect is most probably mediated by a pharmacological mechanism.
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The membrane-integral C-subunits of Arr, Psr/Phs, Unk, Ttr and DMSO reductase thus probably represent a common module employed by these molybdopterin enzymes for the purpose of membrane attachment and, most probably, mediating electron exchange with the quinone pool.
As all Nec-1 derivatives were protective at high dose, this effect most probably is mediated by RIPK1 inhibition.
Since risperidone scarcely prolongs QTc (< 4 ms) in a general population (with a priori a wild-type KCNH2) [ 14], the sensitivity to this drug in our patient (also carrying only wild-type alleles of this gene) is most probably not mediated by the KCNH2.
Most of these effects are probably mediated through the main target enzyme [30].
Leukopenia is one of the most frequent extraglandular manifestations of the disease and is probably mediated by antineutrophil antibodies [ 29].
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