According to our models, the cytosolic diffusion restrictions leading to intracellular compartmentalization and functional coupling between ATP-consuming and ATP-producing organelles are most probably localized in certain areas of the cell (12,13).
Thus, levels of these substances will most probably increase over time in certain compartments.
A certain activator, most probably ATP, binds to MPDM motif (or another motif) and drives the conformational change of HKTs, and then the cation switch turned on.
Interestingly, glucose deprivation has been demonstrated to also enhance chemosensitivity of certain tumors, most probably via interference with the availability of sufficient energy substrates for effective DNA damage responses (Simons et al, 2007; Aghaee et al, 2012; Dittmann et al, 2013).
Finally, I would like to thank Dr. Fyodor Kondrashov, who is not only a referee but also a coeditor of this paper for Biology Direct, for his fairness in handling a manuscript with which he does not agree, and for his courage to write an open review for a work most probably strange - but with a certain non-negligible potentiality of importance.
MHC molecules encoded by individual loci derived from duplication would then have become available to co-evolve with certain lymphocytes' receptors, most probably various forms of γδ TCRs.
In our study, lower tree canopy cover was related to a higher density of medicinal plants under forest degraded by logging, most probably due to the presence of certain species adapted to sunny conditions.
This would mean that a certain proportion of the patients born abroad most probably received help from relatives or friends to fill in the questionnaire.
As this oscillation most probably corresponds to the subjects' sleep stage rhythmicity a close relationship also to certain HRV parameters was expected (see discussion).
