Sentence examples for most primitive stem from inspiring English sources

These results suggest that the most primitive stem cells, which are located even further away from BM sinuses, are likely located in a very low pO2 environment.

"This is borne out by the fact that Hesperornis — discovered by Othniel Charles Marsh of the Yale Peabody Museum of Natural History — which is a near relative of modern birds that still retains teeth and the most primitive stem avian with a modernized beak in the form of fused, elongate premaxillae, also possesses a modern bird palatine bone," he said.

In particular, the most primitive stem cells (from a developmental point of view) are present at very low frequencies in adult tissues.

Unfortunately, optimized expansion protocols for the most primitive stem cells have not been described so far, and during expansion these most primitive cells decrease in number due to their differentiation into more mature progenitors [5].

Unravelling the mechanisms that govern the quiescence of the most primitive stem cells in adult tissues is of primary importance in developing expansion strategies for these rare cells that will allow their application in the clinic [6].

The metabolic rate of the most primitive stem cells, the "very small embryonic-epiblast stem cells"(VSELs), as judged from extreme paucity of their cytoplasmic content and few mitochondria, is expected to be indeed minimal [ 50].

Based on these data, we proposed that epiblast-derived VSELs, which are deposited in adult tissues as a population of most-primitive stem cells involved in tissue/organ rejuvenation, are depleted by chronic Ins/Igf signaling.

Morita Y, Ema H, Nakauchi H. Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment.

It was noted that the most primitive germline stem cells, oogonia, were not readily distinguishable from stage I follicles.

The most primitive embryonic stem cells (ESCs), derived from the developing blastocyst, have diploid karyotypes that can remain stable after many passages in vitro [1], [2].

Hence the challenge is to understand which drugs should be combined with which chemotherapeutic agents in order to eradicate even the most primitive cancer stem cells (reviewed in [23]).