Sentence examples for most primitive cells from inspiring English sources

Other neurologists were more cautious, among them, Dr. Evan Snyder at Harvard Medical School and Children's Hospital in Boston, one of the first to isolate the most primitive cells of the brain.

Unfortunately, optimized expansion protocols for the most primitive stem cells have not been described so far, and during expansion these most primitive cells decrease in number due to their differentiation into more mature progenitors [5].

The Reynolds' group showed that the stressful growth conditions of their system due to serum starvation allows dedifferentiation of certain cells, or selects for the most primitive cells by eliminating the differentiated cells that are unable to survive.

Totipotent cells are the most primitive cells, followed by pluripotent cells.

For this reason, cell-cycle-specific drug, such as taxanes, are expected to exert little effect on most primitive cells.

However, CK6 expression was generally absent in the basal, rapidly dividing cell layer, which is expected to contain the least differentiated, most "primitive" cells.

These include cells that are myoepithelial/basal-restricted, luminal-restricted, or bipotent, the latter representing the most primitive cell within the breast lineage hierarchy that can be quantified in vitro (Stingl et al, 2001).

The quiescent leukemic stem cell or early PCs functioning as LSCs are known to be concentrated in the most primitive cell compartments, because like normal cells, once stem or early PCs become committed to differentiation and maturation, they continue to proliferate.

LSK cells represent a heterogeneous cell population containing the most primitive haematopoietic cells that have self-renewal capacity and haematopoietic progenitors that give rise to all mature cell types found in peripheral blood for a lifetime (Ikuta & Weissman, 1992).

Although pluripotency is not formally required for the definition of a stem cell, studies of the haematopoietic system and other stem cell compartments have revealed that the most primitive stem cells have the greatest developmental potential.

The metabolic rate of the most primitive stem cells, the "very small embryonic-epiblast stem cells"(VSELs), as judged from extreme paucity of their cytoplasmic content and few mitochondria, is expected to be indeed minimal [ 50].