Sentence examples for most primitive HSCs from inspiring English sources

Therefore, myeloid-biased HSCs were thought to be most primitive HSCs in the murine HSC hierarchy.

This is consistent with previous evidence that longer cell-cycle transit times correlate with the most primitive HSCs (Dykstra et al., 2006, Lutolf et al., 2009, Yamazaki et al., 2009).

Furthermore, after the number of molecular analyses and in vivo experiments performed by Ratajczak et al., it has been recently proposed that human CB-derived VSELs correspond to the population of the most primitive HSCs circulating in the PB [ 32].

At the same time, adipocytes appear to positively influence the most primitive HSC, suggesting that they prevent hematopoietic progenitor expansion while preserving the hematopoietic stem cell pool.

The proportion of the most primitive HSC (CD34+ CD133+ CD38−) has been reported higher in grafts from patients with lymphomas mobilized with chemotherapy/G-CSF plus plerixafor [ 46].

The most HA-rich regions of the bone marrow stroma are the endosteum and the sinusoidal endothelium, the sites that are considered the niches of the most primitive HSC.

These slowly dividing HSCs represented the most primitive subset of HSCs, and enhancement of their proliferation kinetics in steady state, but not after cytostatic stress, marked a primary event associated with loss of HSC self-renewal.

It was recently reported that murine most primitive CD150high or vWF+ HSCs showed megakaryocyte primed gene expression patterns, and in the CFC assay, they formed more megakaryocyte containing colonies compared with CD150int or vWF- HSCs.

Data compiled from numerous investigators have indicated that the most primitive hematopoietic cells including the HSCs reside in a lineage-negative sub-population with a CD34+ CD38− CD90+ CD45RA− phenotype.

These data demonstrate that isolation and functional evaluation of cells based on their past proliferation kinetics can be used to identify the most primitive subset of cells within the HSC compartment, and that changes in proliferative behavior to a large extent precede the changes in HSC phenotype that accompany loss of HSC self-renewal.

We therefore concluded that non-HSCs are the most primitive cells, enriched in VSEL SCs, from among the populations examined in our study, whereas HSCs could be defined as more differentiated cells.