While the majority of zinc finger proteins were found among prezygotic transcripts, 73% of transcription factors with homeodomain were activated during SGM, while forkhead proteins occupied an intermediate position.
Prezygotic transcripts included multiple regulators that are most likely involved in developmental processes that take place long after fertilization, such as components of ErbB, hedgehog, notch, retinoid, TGFb, VEGF and Wnt signaling pathways, as well as transcripts involved in the development of nervous system.
Functional groups involved in degradation of proteins and RNA were represented almost exclusively by prezygotic transcripts that suggested a profound reconstruction of the cellular machinery.
Maternally provided mRNA comprised the major part of prezygotic transcripts while the putative paternal contribution was small, but sperm transcripts might play important roles of in the establishing of early embryonic gene expression profiles [ 5, 61, 62].
Though a number of genes related to chromosome maintenance and remodeling were present among prezygotic transcripts, major changes took place at MBT and a large fraction of the activated genes encoded histones (66 genes).
Most transcripts identified so far are poly A+ transcripts, whereas the poly A- transcripts remain largely unknown.
Most PHGPx transcripts originated from pseudogene 1.
Ex is the top most expressed transcripts that represent x% of the data.
In general, most regulated transcripts were specific for the different dose levels where few transcripts were affected at more than one dose level.
Second, unlike most texts, transcripts are unstructured, lacking sentence boundary markers and paragraphs.
