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In contrast to most previous trials, the adjudication comprised all possible non-CV and CV events.
In most previous trials investigating pharmacological treatment for NAFLD, dietetic surveillance was poorly described.
The complexity of delivering community-based interventions targeting children probably explains why most previous trials are school based.
Most previous trials have investigated patients with hyperlipidaemia, and the relatively low baseline cholesterol in our study population may have contributed to the neutral lipid results.
As most previous trials have demonstrated the effectiveness of stimulants on ADHD symptoms, it was not fully understood if symptomatic improvements translated into functional improvements.
This void is partly because most previous trials were underpowered to examine the effect of exercise on injurious falls, in particular the most severe falls.
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Most previous clinical trials of detemir given in basal-bolus therapy for type 1 diabetes used a twice-daily dosing schedule.
Although most previous therapeutic trials in sepsis have focused on blockade of the initial hyper-inflammatory phase, there is increased recognition that if patients survive this initial stage of the disorder, they progress to an immunosuppressive state [ 4, 28- 32].
However, most previous clinical trials have not demonstrated adequate proof of immunotherapy efficacy for advanced HCC., On the other hand, our clinical trial of glypican-3 GPC3 -derived glypican-3 GPC3 -derivedadvanced HCC demonstrated that the induction of peptide-specific cytotoxic T lymphocytes (CTLs) siglypican-3 GPC3 -derivedith peptide survaccine
For practical reasons, most previous supplementation trials have started after the onset of pregnancy, generally toward the end of the first trimester or later, thereby missing important processes in early pregnancy that influence fetal growth and later health and function such as periconceptional epigenetic changes, placentation, and organogenesis (10– 10).
For the most part, previous trials did not report whether the antiproteinuric effects of n-3 PUFA were affected by the concurrent use of RAAS inhibition, but similar results were reported in a trial of patients with immunoglobulin A nephropathy treated with RAAS.
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