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AR-v7 is the most prevalent variant expressed in about 60% of CRPC tumors.
The genetic distance of each variant from the most prevalent variant in the first sample of the patient was calculated by computing pair-wise distance in MEGA 4.0 using the Tamura-Nei model with gamma distributed rates across sites (α = 0.5) [23].
KPC-2 is clearly the most prevalent variant in Europe [ 12, 35].
S556G, which confers 30-fold resistance to dasabuvir (13), was the most prevalent variant in GT1a.
M28V, which confers 58-fold resistance to ombitasvir in the GT1a replicon (11), was the most prevalent variant in GT1a.
Previous reports on adults and children in the region have confirmed that in Malawi HIV-1 subtype C is the most prevalent variant [ 48, 49].
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The most prevalent variants of these chimeric oncogenes are RET/PTC1 (60 to 70%) and RET/PTC3 (20 to 30%) [ 1, 3- 5].
The most prevalent variants (70%) were the European variants (E), followed by Asian American (AA) variants (22.5%) and African (Af) variants (2.5%).
M28V in GT1a and Y93H in GT1b were the most prevalent preexisting variants in NS5A, and C316N in GT1b and S556G in both GT1a and GT1b were the most prevalent variants in NS5B.
This variant was described as one of the most prevalent variants among young adults in Tanzania, Dar-es-Salaam [ 14] and adults in the Kilimangiaro, Kagera and Mwanza regions [ 13, 15].
Aβ is generated through the sequential processing of the amyloid precursor protein (APP) by the β-secretase (BACE1) and the γ-secretase complex, and occurs in various isoforms between 36 and 46 amino acids in length, with Aβ40 and Aβ42 being the most prevalent variants [ 4- 6].
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