Sentence examples for most prevalent mutations from inspiring English sources

TP53 and CTNNB1 are the next most prevalent mutations, affecting 25%−30% of HCC patients, that, in addition to low-frequency mutated genes (eg, AXIN1, ARID2, ARID1A, TSC1/TSC2, RPS6KA3, KEAP1, MLL2), help define some of the core deregulated pathways in HCC.

The assay based on reverse hybridization principle simultaneously detects 13 different mutations affecting 6 independent codons, including the most prevalent mutations at positions 531 and 526.

The article also throws light on the SAR studies and most prevalent mutations in the receptor for designing CCR5 antagonists that can combat HIV-1 infection.

Among the most prevalent mutations, reversion of M184V was associated with the largest ΔRC.

The most prevalent mutations at baseline were M41L (73.8% of patients), M184V, and T215Y (69%, 66.7% respectively).

Consistent with this hypothesis, we have recently shown that Pol IV activity is an essential ingredient to establish mucA as the main target for mutagenesis in mucoid conversion, with this factor having a prominent role in the generation of -1 deletion in a monomeric simple sequence repeats of five Gs G5-SSR4266) ofe of the most prevalent mutations among CF mucoid isolates [30].

Results: The most prevalent mutation, Q188R, had a significant effect of genotype category (Q188R/Q188R, Q188R/Other, Other/Other) on POF (P =.04, Fisher exact test and an odds ratio of 8.3).

The most prevalent mutation, is a splice mutation; the T-to-C transition in position 6 of the 5' splice site (5'ss) of intron 20 (IVS20+6T→C) of this gene.

The most prevalent mutation, G2019S, increases LRRK2's kinase activity, therefore understanding the sites and substrates that LRRK2 phosphorylates is critical to understanding its role in disease aetiology.

Indeed deletion of the F508 residue, which represents the most prevalent mutation in the CFTR, causes a temperature sensitive folding defect leading to protein degradation by the endoplasmic reticulum associated degradation machinery [21].

Using mutagenetic tree models, we found that in this dataset, M184V was the most prevalent mutation and the first to change, followed by the M41L, T215Y pathway or the K103N, K219Q pathway.