Sentence examples for most prevalent mutation from inspiring English sources

Results: The most prevalent mutation, Q188R, had a significant effect of genotype category (Q188R/Q188R, Q188R/Other, Other/Other) on POF (P =.04, Fisher exact test and an odds ratio of 8.3).

The most prevalent mutation, in the MEN-1 gene, occurred in more than 44percentt of all 68 tumors.

The most prevalent mutation, G2019S, increases LRRK2's kinase activity, therefore understanding the sites and substrates that LRRK2 phosphorylates is critical to understanding its role in disease aetiology.

Using mutagenetic tree models, we found that in this dataset, M184V was the most prevalent mutation and the first to change, followed by the M41L, T215Y pathway or the K103N, K219Q pathway.

The most prevalent mutation, is a splice mutation; the T-to-C transition in position 6 of the 5' splice site (5'ss) of intron 20 (IVS20+6T→C) of this gene.

Indeed deletion of the F508 residue, which represents the most prevalent mutation in the CFTR, causes a temperature sensitive folding defect leading to protein degradation by the endoplasmic reticulum associated degradation machinery [21].

TP53 and CTNNB1 are the next most prevalent mutations, affecting 25%−30% of HCC patients, that, in addition to low-frequency mutated genes (eg, AXIN1, ARID2, ARID1A, TSC1/TSC2, RPS6KA3, KEAP1, MLL2), help define some of the core deregulated pathways in HCC.

The assay based on reverse hybridization principle simultaneously detects 13 different mutations affecting 6 independent codons, including the most prevalent mutations at positions 531 and 526.

The article also throws light on the SAR studies and most prevalent mutations in the receptor for designing CCR5 antagonists that can combat HIV-1 infection.

Autosomal-dominant mutations within the nuclear localization signal (NLS) region of FUS are by far the most prevalent mutations and clearly pathogenic3, with the R521C and R521H point mutations being the most common2.

Next, they determined the amino acid makeup, or sequences, of four genes with the most prevalent mutations, including ARID1A, in the tumor and normal tissues of an additional 34 ovarian clear cell cancer patients.