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'most prevalent issue' is a correct and usable phrase in written English.
It can be used in sentences to refer to the most common or widespread problem or concern in a given context. Example: In today's society, mental health concerns are becoming the most prevalent issue among young adults.
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Rising income inequality is quickly becoming the most prevalent issue of our century, "the defining challenge of our time," according to President Obama.
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Since its creation, Ebony has served as a window into the most prevalent issues within black politics, entertainment and culture.
His publications Ebony and Jet have both served as a window into the most prevalent issues within black politics, entertainment and culture.
Although these messages are meant to empower, they actually compound one of the most prevalent issues women face today - the lack of the ability to say "no".
Of the 1994 show, Smith concluded: "Many of contemporary art's most prevalent issues and visual themes are relentlessly apparent: the body, genitalia, gender identity, role reversal, sexual stereotyping, endless jokes and double-entendres.
In the qualitative section, non-transparency of management, lack of goals, administrative problems were among the most prevalent issues observed.
Depressive (34.5%) and anxiety (17.0%) symptoms were also the most prevalent issues for young people accessing eheadspace, followed by difficulty with personal relationships (11.8%) and suicidal thoughts or behaviours (7.9%).
Economic issues are believed to be the most prevalent topic by 9.1%% of INT investors and almost one-fifth of CONV investors.
Child sexual abuse is likely the most prevalent health issue faced by our children today, with a serious array of medical and social consequences that can persist into adulthood.
As a corollary, in this paper, we approached sexual desire issues in older age mainly through psychosocial explanations as we targeted the biopsychosocial factors impacting older women's sexual desire in particular, motivated by research finding such as those of Gefland [ 4], who reported that the most prevalent sexual issue in this population is indeed inhibited sexual desire (77%).
ClinicalTrials.gov number NCT00934570 Childhood obesity is one of the most prevalent health issues affecting children in developed countries globally.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com