Metabolic stress induced by nutrient overload (that is, excess glucose) can occur as a result of multiple mechanisms, of which the most prevalent are increased production of mitochondrial NADH (that is, increased NADH/NAD + ratio) and concomitant elevated production of endogenous reactive oxygen species (ROS) as a result of leakage of electrons from the mitochondrial respiratory chain.
The size distribution remains qualitatively the same with increasing immersion time up to 40 s, but the average and most prevalent sizes increase.
The age-related epithelial cancers of the breast, colorectum and prostate are the most prevalent and are increasing in our aging populations.
Again, for both model architectures, additive and dominance effects were most prevalent, but epistasis increased substantially as allelic effects approached null.
The most prevalent mutation, G2019S, increases LRRK2's kinase activity, therefore understanding the sites and substrates that LRRK2 phosphorylates is critical to understanding its role in disease aetiology.
Prevotella was the most prevalent genus and increased in the solid fraction.
The monthly numbers of shigellosis/dysentery, typhoid fever, and cholera cases reported in Vietnam during 1991 2001 are shown in Figure 2. Shigellosis/dysentery was the most prevalent disease and increased approximately 2.5 times during the study period, with 16,976 cases (annual IR of 25.3 per 100,000) reported in 1991 compared with 46,292 cases (IR, 58.8) in 2001.
Data from both North America and Europe have shown S. pneumoniae serotype 19A (Spn19A) to be the most prevalent serotype, associated with increasing rates of MDR [ 19].
Hepatocellular carcinoma (HCC) is one of the most prevalent cancers with steadily increasing incidence even in developed countries, such as Europe and the United States (El-Serag, 2002).
We demonstrate that two out of three cancer-associated TERT mutations caused no effect and only the most prevalent promoter mutations mildly increased TERT levels in hESCs, which did not result in significantly increased telomerase activity.
