Sentence examples for most prevalent alterations from inspiring English sources

Missense mutations are the most prevalent alterations (75%) located mainly within the DNA binding domain.

Microarray analysis identified among the most prevalent alterations in cervical tumors and cell lines the amplification of the RBP1- Retinoletinol binding protein 1 and 2, 58.8%) and Tp63 (52.9% of the samples) genes, located at 3q21-q22 and 3q27-q29, respectively.

Recently, an innovative approach based on inhibitors of the mutated BRAF gene (which represents the most prevalent alteration in melanoma patients) appears very promising from the clinical point of view.

In paediatric PTC (spontaneous and radio-induced), RET/PTC rearrangements are the most prevalent alteration (60 80%), while BRAF point mutation is only observed in about 4% of the cases (Nikiforov, 2002; Xing, 2005).

At codon 13, the most prevalent modification was Gly13Asp (GGC > GAC), followed by other low frequent alterations.

Ossicular lesions represent the most prevalent change.

Future work to characterize the structures of the glycans using mass spectrometry should be compared to these gene expression results to piece together the links between the biosynthetic pathways and the most prevalent glycan alterations in EMT.

Accumulation of genetic and epigenetic changes plays an important role in the process of hepatocarcinogenesis. Chromosomal aberration is among the most prevalent genetic alterations observed in HCC [ 1].

FLT3 and NPM1 mutations have been shown to be the most prevalent somatic alterations in AML, particularly in cytogenetically normal AML.

Also analyzing the various patterns of the combined hyperlipidemia the most prevalent were alterations in TG plus HDL-chol and LDL-chol plus HDL-chol, respectively 35 and 32% ; total cholesterol plus TG and HDL-chol in 38%and11%1% of patients had four different lipidic parameters altered.

Among the most prevalent oral alterations in prematurely borne (i.e. a new borne of less than 37 weeks gestation) and low birth weight children (i.e. less than 2500 gram at birth) are hypoplasia and opacities in the dental enamel [ 13, 21- 23].