Sentence examples for most prevalent alteration from inspiring English sources

In paediatric PTC (spontaneous and radio-induced), RET/PTC rearrangements are the most prevalent alteration (60 80%), while BRAF point mutation is only observed in about 4% of the cases (Nikiforov, 2002; Xing, 2005).

Recently, an innovative approach based on inhibitors of the mutated BRAF gene (which represents the most prevalent alteration in melanoma patients) appears very promising from the clinical point of view.

Missense mutations are the most prevalent alterations (75%) located mainly within the DNA binding domain.

Microarray analysis identified among the most prevalent alterations in cervical tumors and cell lines the amplification of the RBP1- Retinoletinol binding protein 1 and 2, 58.8%) and Tp63 (52.9% of the samples) genes, located at 3q21-q22 and 3q27-q29, respectively.

At codon 13, the most prevalent modification was Gly13Asp (GGC > GAC), followed by other low frequent alterations.

Ossicular lesions represent the most prevalent change.

C > T substitution is the most prevalent base alteration in most cancers and even more prominent among harmful substitutions leading to amino acid alterations (Additional file 2: Figure. S1).

All mutations identified in the prevalence set are shown in Additional file 12. Unsurprisingly, the most prevalent genetic alteration detected in this cohort comprised a broad spectrum of TP53 mutations (38.3 %).

The c.5266dupC mutation is the most prevalent BRCA1 alteration in Europe and a geographic distribution of this mutation is consistent with its Baltic origin [ 19].

Nevertheless, more than half of melanomas express the mutationally activated BRAF (V600E, the most prevalent genetic alteration) oncoprotein, which triggers the BRAF-MEK-ERK signaling pathway (MAPK pathway), a key regulator of proliferation and differentiation.

Future work to characterize the structures of the glycans using mass spectrometry should be compared to these gene expression results to piece together the links between the biosynthetic pathways and the most prevalent glycan alterations in EMT.