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Moreover, most predictive indices for volume responsiveness are not validated in patients receiving lung protective ventilatory strategies.
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Furthermore, the most predictive indexes will be selected to seek the optimal cut point within the 30th to 70th percentile for all patients in 5th-percentile step.
A previous study in a Turkish population showed that the WHtR is the most predictive indicator among the anthropometric indices; however, visceral fat measured with bioimpedance analysis is a more sensitive variable than the WHtR [ 16].
Validated in vitro pharmacokinetic/pharmacodynamic (PK/PD) and animal infection models have been employed to identify the most predictive PK/PD indices and serve as key tools in the antibiotic development process.
The aim of our study was to work out the most predictive qEEG indexes of DCI.
The authors reported that fAUC/MIC was the most predictive PK/PD index that correlated best with colistin efficacy against these Gram-negative pathogens in both thigh and lung infection models.
It should be noted that recently Dudhani et al. used two murine infection models to identify the most predictive PK/PD index of the antibacterial activity of colistin against P. aeruginosa and A. baumannii strains.
Most of these predictive indices have been criticized as being too subjective, complex, and difficult to apply universally.
Overall, the combined c-index for all variables included in the final Cox model for CSS (Table 2b) was 87% with stage proving to be the most predictive factor (univariate c-index of 79%).
Several animal infection models have identified that the fluoroquinolones display the characteristics of concentration-dependent killing and the AUC/MIC ratio is the PK/PD index most predictive of the antibacterial effect [ 16, 25].
Log of CRP was the most predictive factor for OS (c-index of 70%) and the second most predictive factor after stage for CSS, increasing the predictive capacity from 81 to 86%.
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