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VEGF121 and VEGF165 are the only soluble isoforms and also the most abundant, with VEGF165 being the most powerful stimulator of endothelial cell proliferation (Soker et al, 1997).
The finding is consistent with studies showing that among the cytokines, TNFα is the most powerful stimulator of osteoclastogenesis [ 4- 7].
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In this study, we examined the effects of HA species on the expression of ADAMTS1, 4, 5, 8, 9 and 15 in osteoarthritic chondrocytes stimulated with IL1, one of the most powerful stimulators of proteinase production.
One of the most powerful stimulators of adult neurogenesis is exercise [ 77, 78]; an effect believed to be at least partly due to enhanced blood flow and increased delivery of growth factors.
Vascular endothelial growth factor (VEGF) appears to be the most potent stimulator of formation and progression of pterygium.
It was also suggested that BMP9 is the most potent stimulator of hepcidin [ 24].
Accumulating evidence suggests that AngII is the most potent stimulator of VSMC proliferation [ 4, 7].
TCA is a hydrophilic bile acid, acting as the most potent stimulator of cholangiocarcinoma cell growth.
The most potent stimulator for PCT induction under experimental conditions is the systemic effect of bacterial endotoxins [ 23].
The most powerful constitutional power was imperium.
Insulin is a powerful stimulator of protein synthesis, and leucine is known to stimulate insulin secretion.
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CEO of Professional Science Editing for Scientists @ prosciediting.com