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Among these compounds, compound 12b was the most potent with 6.5 μM of IC50.
Compound 7c was the most potent with IC50 of 24 nM.
Compounds 5e, 5g and 5v were the most potent, with LC50 values of 23.72, 2.04, and 20.01 mg/L, respectively.
Among all these compounds, 4b was found to be the most potent with IC50 = 1.09±0.004 μM.
Among these compounds, 2b and 3a were the most potent with 6.5 and 1.1 μM of EC50, respectively.
These phosphonucleotides are potent inhibitors with C3′p being the most potent with a Ki value of 22 μM.
Similar(14)
Among the compounds tested, the compounds 7i and 8g displayed most potent activity with MIC value of 1.56 µg/mL with low cytotoxicity.
In particular, compound P3 displayed the most potent activity with IC50 value of 0.017 μM comparable with that of Imatinib.
NF-4 with p-fluoro phenyl ring was the most potent inhibitor with IC50 value of 0.62 μM.
As expected, compound 8e with an n-decyl at position 8 had the most potent activity with an MIC of 1.0 μg/mL.
Compound 5j is the most potent one with MIC80 value 1.5 μg/mL against Trichophyton rubrum.
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