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The most potent variant achieved 2110-fold affimprovementvementoto an equilibrium dissociation constant (Kd) of 3.45 pM with only 7 amino acid substitutions.
By fluorescence microscopy and flow cytometry, we found that Tat72 was the most potent variant of Tat to trigger apoptosis.
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DOI: http://dx.doi.org/10.7554/eLife.01483.015 We exposed the DNA repair-defective tumor cell line HCT-116 (Wacker et al., 2012) to cytotoxic concentrations of CT9, our most potent cotransin variant (see 'Materials and methods' for details).
Why not one mismatch or penta-/heptanucleotides, why is the spacer introduced?" Authors' response: The presented statistical model is only the most potent one amongst the tested variants.
This variant is the most potent gene transactivator among the NF-κB family and is the major NF-κB protein found in the nucleus of cytokine-stimulated cells.
MONDAY, Dec. 22 (HealthDay News) -- People may face an increased risk of lung cancer if they have a gene variant that metabolizes the most potent of cigarette smoke carcinogens, a new study says.
The IL-6 variant Sant 7 was identified as the most potent superantagonist and it was able to inhibit the IL-6-stimulated growth of several different malignant cell types.
The most potent compounds show below 10 nanomolar activity towards wild-type HIV-1 and variants bearing Tyr181Cys and Lys103Asn/Tyr181Cys resistance mutations.
In this paper, twenty one compounds displayed variant inhibitory activities against BTK in vitro, and compound 14g showed the most potent inhibitory activity against BTK enzyme, with the IC50 value of 12.8 nM.
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CEO of Professional Science Editing for Scientists @ prosciediting.com