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But the most potent type of glacial flood is caused by an erupting volcano.
This confirmed the findings by Reutterer et al. that LO28 is the most potent type I IFN stimulator amongst the commonly used Listeria strains [31].
Among the different types of APCs (i.e., dendritic cells, monocytes, macrophages, and B cells), dendritic cells are the most potent type and can be further differentiated into myeloid or plasmacytoid cells.
DCs are the most potent type of the antigen-presenting cells (APC) and play a critical role in the initiation of immunity by producing soluble factors such as chemokines and cytokines [ 1].
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Among them, compound 10e (IC50 = 8.17 ± 0.48 nM) showed the most potent T-type calcium current blocking activity and higher potency than Mibefradil (IC50 = 1.34 ± 0.49 μM).
Among those compounds synthesized, the compound 1n shows the most potent T-type calcium current blocking activity with an IC50 value of 1.52 μM, which is comparable to that of mibefradil.
BI 2536 is the most potent ATP-competitive type inhibitor of PLK-1, arresting a large number of cell lines in the G2/M phase with mitotic abnormalities, such as the monopolar spindle and aberrant accumulation of cyclin B1 [ 16, 31].
Two of the compounds identified in our study are the most potent abietane-type anti-biofilm agents reported so far and display robust activity against pre-formed biofilms at concentrations only 3 6-fold higher than those required to inhibit biofilm formation.
Indeed, the change causing the most potent C-type gate stabilization, G137I, made the channels completely resistant to ML67-33 activation.
We then screened them using whole-cell voltage clamp techniques to identify the most potent T-type calcium channel inhibitors.
The most potent and versatile type of stem cell comes from very early embryos.
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