However, the most recent discussion clearly indicated that patients are likely to derive greatest benefit from early treatment with the most potent antibiotic therapy, such as amoxicillin/clavulanate and respiratory fluoroquinolones which have a broad spectrum of activity against likely pathogens [ 23].
Oncologists and patients now face an important choice when selecting adjuvant endocrine treatment [ 66, 100], whether to start with the most potent endocrine therapy (an AI) upfront or to start with tamoxifen and switch to an AI inhibitor after 2 5 years.
Since CYC is one of the most potent immunosuppressive therapies, and has been used to treat severe manifestations of a variety of autoimmune and inflammatory diseases, it might be possible to use IV CYC to treat patients with underlying AOSD who have treatment-refractory or life-threatening disease.
Bone and cartilage repair is considered an unmet need in patients with RA, since even the most potent anti-inflammatory therapies to date do not reverse bone loss and articular damage.
Once internalized into the cytosol, one molecule of IT is sufficient to kill the cell, making it the most potent strategy for anticancer therapy.
In addition, endoxifen was recently proven to be the most potent metabolite in tamoxifen therapy with respect to the growth inhibition of breast cancer cells (Wu et al, 2009).
However, intensive statin therapy with the most potent statins (atorvastatin, rosuvastatin and even pitavastatin) does not completely eliminate the residual cardiovascular risk associated with high TG.
To construct the index, we determined which of four levels of analgesic drug therapy was the most potent one used: 0, no analgesic drug; 1, a non-opioid (e.g., a non-steroidal anti-inflammatory drug); 2, a weak opioid (e.g., codeine or tramadol); and 3, a strong opioid (e.g., morphine, fentanyl, buprenorphine, oxycodone and so on).
Human Immunodeficiency Virus Type 1 (HIV-1) protease inhibitors (PIs) are the most potent class of drugs in antiretroviral therapies.
Treg therapy on its own seems most potent if hosts are lymphopenic (47) or if Tregs are designed to express a specific TCR (16, 17, 29).
