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For TNF, MIP-2α and IP10, LPS was always the most potent stimulus, but the TLR2 agonists were effective as well.
Since pupil constriction could be considered as a defensive mechanism against PSE, Red/Blue combination is considered the most potent stimulus, amongst other colour combinations, in eliciting PSE.
While there is no question that resistance exercise is the most potent stimulus for the promotion of strength and FFM gains, adjunctive strategies to augment these effects may enhance the overall efficacy of strength training interventions.
Among amino acids, arginine is the most potent stimulus to insulin and glucagon secretion.
Vasopressin levels increase early in septic shock because hypotension is the most potent stimulus for release and synthesis of vasopressin.
Vasopressin levels increase early in septic shock because hypotension is the most potent stimulus for release of stored vasopressin.
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Surprisingly, monocyte activation by dCGN to produce TNF was much stronger than the activation induced by LPS, an inflammatory factor considered to be among the most potent stimuli for leukocyte activation.
Since it has been suggested that the Nrf2/ARE pathway is crucial for the regulation of intracellular redox state [16] and oxidative stress is one of the most potent stimuli for Nrf2/ARE pathway activation [28], a first conclusion of this study is that heavy smokers, contrary to moderate smokers, do not appropriately react in terms of Nrf2/ARE activation to the intracellular oxidative stress.
Mitochondrial uncoupling is one of the most potent stimuli for lactate production.
2 Chronic inflammation in the cirrhotic liver induces architectural and functional changes that result in hypoxia, one of the most potent stimuli for angiogenesis.
This is intriguing given that TSLP activated dendritic cells (TSLP DCs) appear to be one of the most potent stimuli of IL17RB expression [ 27].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com