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VEGF is one of the most potent stimulators of angiogenesis by stimulating the proliferation and migration of vascular endothelial cells [30] [32].
VEGF-A is one of the most potent stimulators of angiogenesis identified thus far, affecting endothelial cell vascular permeability, proliferation, and motility [7].
The development of new vessels is influenced by pro-angiogenic factors, vascular endothelial growth factor (VEGF) being one of the most potent stimulators of angiogenesis (Ferrara, 1999).
Although hypoxia is one of the most potent stimulators of VEGF, interestingly, not all of the in situ and invasive cancers expressed HIF-1 α.
GLP-1 has two major isoforms (7-36 andde and 7-37) which are among the most potent stimulators of glucose-dependent insulin secretion.
Thus, our data further suggest that VEGF and b-FGF may have a relevant role in the inflammatory phenomenon seen in GO. b-FGF, produced by endothelial cells and fibroblasts, is one of the most potent stimulators of angiogenesis and is mitogenic and chemotactic for both endothelial cells and fibroblasts [ 13– 15].
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In AMs, the October coarse PM was the most potent stimulator for IL-6 release, whereas the July PM consistently stimulated the highest ROS production measured by dichlorofluorescein acetate and dihydrorhodamine 123 (DHR).
Vascular endothelial growth factor (VEGF) appears to be the most potent stimulator of formation and progression of pterygium.
Although bone morphogenetic protein-2 (BMP-2) is known to be the most potent stimulator available for bone formation, a major barrier to widespread clinical use is its inherent instability and absence of an adequate delivery system.
His team mixed the human version of sir2 with 10,000 chemicals, searching for ones that boosted activity; the most potent stimulator they found was resveratrol, a chemical found in red wine and theorized to be responsible for red wine's apparent cardiovascular benefits.
It was also suggested that BMP9 is the most potent stimulator of hepcidin [ 24].
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