Sentence examples for most potent regulator from inspiring English sources

Thus, it is likely that rosiglitazone-mediated activation of PPARγ1 in DLK-depleted cells is sufficient to displace the repressive mSin3A/HDAC1 complex from the cebpα promoter and allow the expression of C/EBPα, which in turn induces PPARγ2, the most potent regulator of adipogenesis [44].

This reaction is promoted by gastric acidity and ascorbic acid, which is thus considered the most potent regulator of iron absorption [ 19].

Previous studies have shown that TGF- β/BMP is the most potent regulator of osteogenesis in various cell types and experimental conditions [ 52– 52].

Active vitamin D is the most potent regulator of FGF23 and acts directly on FGF23 gene transcription by binding a vitamin D-responsive element in the gene promoter region [ 11].

Although it is well known that hypoxia is the most potent regulator of VEGF gene expression and protein production [ 35], an oxygen-independent up-regulation of VEGF and vascular barrier dysfunction has been observed [ 36].

That affected individuals in families with 'loss of function' mutations in the gene encoding URAT1 (SLC22A12) demonstrate hypouricemia and hyperuricosuria as well as functional renal impairment supports the suggestion that URAT1 is the most potent regulator of serum urate levels [ 13, 14].

TF is known to induce vascular endothelial growth factor (VEGF), one of the most potent regulators of angiogenesis, which in turn up-regulates the expression of TF by activating the early growth response-1 gene (Mechtcheriakova et al. 1999).

One of the most potent regulators of VEGF expression is HIF-1α.

Growth factors such as VEGF, bFGF, and TGF-β are some of the most potent regulators of angiogenesis.

For PP2C-class of phosphatases, divalent ions other than Mn2+/Mg2+ can inhibit their activity by competitively replacing the Mn2+ in the core enzyme structure [27] and Zn2+ are the most potent regulators, having comparable ionic radii with that of Mn2+.

ERK8 is one of the most potent regulators we identified.