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In Cox regression models, NT-pro-BNP-0 h, NT-pro-BNP-48 h and increase/decrease of NT-pro-BNP were independent predictors of ICU mortality within 28 days, with NT-pro-BNP-48 h being the most potent parameter (NT-pro-BNP-0 h Wald 11.289, P = 0.001; NT-pro-BNP-48 h Wald 17.630, P < 0.001; increase/decrease Wald 4.992, P = 0.025, respectively).
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Among all the parameters studied, high temperature and air exposure are the two most potent parameters which accelerate the degradation process.
All the compounds increased the susceptibility of mitochondria to MPT, but, OSI-3701, not affecting the bioenergetic parameters, was the most potent.
Dose-response analyses tentatively indicate that a dose level of 6 mg/kg per day is the most potent, although inequality of baseline clinical parameters between dose groups may be a confounding influence.
Subsequently, the new forcefield parameters are used to understand the precise interactions in the most potent Compstatin analog containing a noncanonical amino acid compared with its unmodified counterpart and the original native sequence.
The most potent compounds underwent evaluation in a broad spectrum of protein kinases, while their pharmacokinetic parameters were measured by LC-MS/MS.
From the ChEMBL, Davis et al. (2011) and Metz et al. (2011), we selected compound-target links with bioactivity parameters IC50, Kd, Ki and potency ≤35 nM to focus on the most potent targets only.
By using these parameters for six selected antiviral drugs, we found that ganciclovir, PMEDAP, and cidofovir are most potent inhibitors of FHV-1 replication in CRFK cells.
By using these parameters for six selected antiviral drugs, we found that ganciclovir, PMEDAP, and cidofovir are the most potent inhibitors of FHV-1 replication in CRFK cells.
Instead he became its most potent critic.
Height is our most potent architectural currency.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com