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Health care issues are among the most potent ones on the campaign trail this year, most particularly the spiraling cost of prescription drugs for the elderly.
Compounds 8c and 11h were identified as the most potent ones, while HL-60, HCT116 and MDA-MB-231 were the most sensitive cell lines.
Compounds 2i l and 4c showed notable anti-inflammatory properties: the most potent ones are 2i (68% inhibition, P < 0.01) and 2l (42% inhibition, P < 0.05) at 12.5 and 6.25 mg kg−1 doses, respectively.
Ten compounds 2 and 4 showed an interesting analgesic activity: the most potent ones are 2j (36% inhibition, P < 0.05) and 4b (77% inhibition, P < 0.01) at 6.25 and 25 mg kg−1 doses, respectively.
In an attempt to design compounds to lower the level of T, we designed androsterone (ADT) derivatives substituted at the position 3β as inhibitors of type 3 17β-HSD, and then selected the eight most potent ones (compounds 1 8) for additional studies.
However, 3-ethoxy-4-hydroxy substituted compound, 5l and 3-methoxy-4-hydroxy substituted compound, 5k are the most potent ones with IC50 of 0.00005 and 0.00012 µM/ml respectively when compared to 5-fluorouracil (IC50 = 0.00615 µM/ml).
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Among them, compound 19 which given chemical name of H72, was the most potent one on gastric cancer cell lines (i.e. MGC803, HGC27, SGC7901) with IC50s ranged from 3.57 to 5.61 μM.
Compound 5j is the most potent one with MIC80 value 1.5 μg/mL against Trichophyton rubrum.
Among them, compound 15d, the most potent one, was selected for further biological evaluation.
Of all the falconry words we learn from Macdonald, the most potent one to appear in "The Goshawk" is "manning".
The most potent one increased the single channel open probability 6 folds with EC50 value of 1.0 μM.
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