Sentence examples for most potent neutralizing from inspiring English sources
Before the recent identification of BNAbs PG9, PG16, VRC01 and VRC02 [12], [12F5 2F5 had been the most potent neutralizing antibody, whereas 4E10 was able to neutralize the broadest range of different viral isolates [13], [14].
In general, RTA interactions were influenced most by the VHH CDR3 (CDR, complementarity-determining region) elements, with the most potent neutralizing antibody having the shortest and most conformationally constrained CDR3.
The most potent neutralizing mAb was CR6261, which demonstrated broad neutralizing activity against a panel of antigenically diverse H5N1 viruses isolated over the last decade (Fig. 3a).
Of the total combinations, the mAb CR6261 was the most potent neutralizing antibodies.
The most potent neutralizing VHH (LT109) was N-glycosylated, resulting in a large increase in molecular mass.
Among the most potent neutralizing antibodies described to date are SUDV-specific mAbs 16F6 (murine) and similar synthetic human mAbs, which can neutralize infection by nearly two logs at midnanomolar concentrations.
For example, Candurra et al. found that hyperimmune rabbit serum was most potent at neutralizing homologous versus heterologous viruses and values against the latter were up to 22-fold lower [ 85].
In the current study, the hybridomas producing well-characterized MAbs 9B4 and 23A2 with the most potent VLY neutralizing activity were selected to construct recombinant single-chain variable fragments of immunoglobulins (scFvs).
The most potent toxin-neutralizing mAbs in this new collection, namely WECB2, TB12, PA1, PH12 and IB2 each had nanamolar (or sub-nanomolar) affinities for ricin and were each capable of passively protecting mice against a 5-10xLD50 toxin challenge.
By IC50 determination, the most potent (SEB-neutralizing) Fabs were 1, 3, 9 and 10, whereas Fabs 7 and 8 had no inhibitory effect (Table 3).
Immune sera from orally inoculated mice were found the most potent to neutralize in vitro dengue infection with neutralizing antibody activities in some cases higher than that obtained with the immune sera from mice i.p. injected with heat-inactivated virus.
